Medically reviewed by Jessica Swirble, PharmDLast updated on March 26, 2025
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Medically reviewed by Jessica Swisher, PharmDLast updated on March 26, 2025
Depressive episodes and the hormonal changes that characterize them can be quite distressing for both the individual and their loved ones. They often feel unwell, fatigue, weight gain, and depression are significant comorbidities. Depressive symptoms are one of the most significant risk factors for suicide and violence in the United States.
Cancer is a common cancer, with estimates reaching about 10,000 cases per year. Approximately 80% of all cases are advanced, with an average survival of approximately 6 years. In contrast, the general population has a 50- to 80-fold higher risk of developing cancers.
In addition to these comorbidities, depressive symptoms are also associated with poor health. The risk of developing depression is greatest in people with a prior history of depression. People with a history of substance abuse and/or substance use disorder are at increased risk of developing depressive symptoms.
Depressive symptoms can persist even after treatment. The symptoms can last for months or years, depending on the person's medical history. Approximately 50% of patients experience at least one depressive episode.
Cancer treatment, including radiation, chemotherapy, and other preventive therapies, can be a challenging process. Some people may develop cancer after the treatment has left them in an advanced stage of their oncology. Treatment often involves chemotherapy or radiation.
Cancer treatment may need to be individualized. Doctors may wish to closely monitor tumor growth and symptoms during treatment and during follow-up.
Depression medications have many side effects. Most patients taking certain antidepressant medications experience mild to severe side effects such as suicidal thoughts or unusual changes in behavior. Some serious side effects of antidepressant medications include blood pressure problems, changes in liver function, and changes in cholesterol levels.
It's important to consult with your healthcare provider before starting any antidepressant medication to ensure it's appropriate for your unique situation.
Call your healthcare provider for medical advice if you have questions about the side effects of an antidepressant medication.
Narcotic pain reliever
Depressive symptoms can be uncomfortable and bothersome. Many people find that they are more comfortable with pain relief from muscle and bone pain. However, a muscle relaxer may be beneficial for some patients. This medication is not recommended for people who are at risk of experiencing a nerve-related adverse reaction.
Cancer pain relievers are a valuable part of managing depression. They work by relieving pain and promoting a sense of calm.
Objective:Treatment of major depressive disorder (MDD) in elderly patients with comorbidity is often limited. We therefore sought to determine the impact of baclofen on depressive symptoms in elderly patients with comorbid MDD and to examine its effect on the overall quality of life.
Design and setting: We conducted a randomized clinical trial. The trial was conducted at the University of Pittsburgh. Eligible patients with MDD (n=942) were randomized to receive either baclofen (10mg) or a placebo (0.05mg) in a 7-day course of treatment. Baclofen (1mg) was added to standard care, with no adjustment for baseline severity.
Patient characteristics: Demographics, comorbidities, and treatment outcomes were assessed at baseline, 8 weeks, and 16 weeks.
Data sources: Patient demographics, comorbidities, treatment outcomes, and medication use were collected and analyzed.
Results: Baclofen improved depression symptoms by significantly improving the total score on the Hamilton Rating Scale for Depression (HAM-D) on the Yale-Brown Obsessive-Compulsive Scale (y-BOCS). The mean change from baseline in the Hamilton Rating Scale for Depression was −1.4 on the first day of treatment and −1.0 on the second day. At the 8-week visit, patients had significantly improved their scores on the Hamilton Rating Scale for Depression on the Yale-Brown Obsessive-Compulsive Scale (y-BOCS), and the mean score improvements were −0.9 on the first day and −1.8 on the second day. At the 16-week visit, patients had a significantly improved score on the Hamilton Rating Scale for Depression on the Yale-Brown Obsessive-Compulsive Scale (y-BOCS) and the mean score improvements were −1.5 on the first day and −1.3 on the second day. The change from baseline to the 16-week visit was −0.5 on the first day and −0.9 on the second day.
Conclusion: Baclofen improved depressive symptoms in elderly patients with comorbid MDD, and improved the overall quality of life. The impact of baclofen on the overall quality of life of patients with MDD was not significantly different from placebo at the 8-week visit. These findings support the hypothesis that baclofen improves depressive symptoms in patients with MDD.
1.2.1. Research Summary: Baclofen (benzoxazosin) improves depressive symptoms in patients with MDD. A small but significant improvement was noted at the 8-week visit and the mean improvement was −0.5. A 5-year safety study has been published with baclofen in elderly patients with MDD. There are no adequate clinical trials to assess the efficacy of baclofen in patients with MDD.Introduction: This study was a randomized, controlled, double-blind, controlled trial conducted at the University of Pittsburgh. The primary objective was to evaluate the efficacy of baclofen for improving depressive symptoms in elderly patients with comorbid MDD and to determine the impact of baclofen on the overall quality of life in these patients.
Methods:A randomized, controlled, double-blind, controlled, parallel-group, multicenter, open-label trial was conducted at the University of Pittsburgh. Eligible patients with MDD were randomized to receive either baclofen (10mg) or a placebo in a 7-day course of treatment. Patients received no additional psychosocial interventions, and the treatment duration was not modified by any intervention.
Results:The primary endpoints were improvement in depressive symptoms by the Hamilton Rating Scale for Depression, the percentage of patients with depressive symptoms improvement and the overall quality of life. The mean change from baseline to the 16-week visit was 0.7 on the first day and 0.9 on the second day. At the 16-week visit, the patients had a significantly improved score on the Hamilton Rating Scale for Depression on the Yale-Brown Obsessive-Compulsive Scale (y-BOCS) and the mean score improvements were −0.6 on the first day and −0.6 on the second day. At the 8-week visit, the mean change from baseline to the 16-week visit was 0.4 on the first day and 0.6 on the second day.
Intrathecal (IT) baclofen is a non-opioid drug that is used for the treatment of spasticity. It works by delivering the intrathecal baclofen into the spinal cord, and thus, increasing the blood supply to the brain [
]. Intrathecal baclofen has been demonstrated to be more effective than oral drugs in reducing the severity of spasticity in rats, which is one of the main therapeutic effects of IT baclofen. It has also been demonstrated to be more effective than the intravenous formulations for the treatment of spasticity, which is due to its long duration of action and the relatively low systemic absorption [
Intrathecal baclofen is an anti-spasticity drug, which is the most widely used non-opioid drug for the treatment of spasticity [
It has been demonstrated to be more effective than oral drugs for the treatment of spasticity, as it has been demonstrated to be more effective than the intrathecal route for the treatment of spasticity in animal models [
Intrathecal baclofen can be administered with the help of a catheter, and it is a relatively inexpensive drug [
Intrathecal baclofen is administered intravenously with a catheter, which is a relatively slow catheter. In the treatment of spasticity, the spasticity is usually achieved by the administration of intrathecal baclofen. Intrathecal baclofen can be administered in doses of 200 mg per day, or up to a maximum of 400 mg per day, depending on the severity of spasticity [
Intrathecal baclofen is a medication that can be administered by the administration of a catheter, and it has been demonstrated that it is more effective than oral drugs in the treatment of spasticity [
Intrathecal baclofen can be administered orally in the form of capsules or tablets, and it is also administered in the form of intrathecal infusion [
Intrathecal baclofen is a non-opioid drug that is used to treat spasticity and to improve the patient’s ability to tolerate the side effects of oral drugs. Intrathecal baclofen is used in the treatment of spasticity in multiple sclerosis and spinal cord injuries [
Intrathecal baclofen can be administered in the form of oral capsules, or it can be injected directly into the spasticity of a patient [
Intrathecal baclofen is administered orally with a catheter, and it is a relatively expensive drug. It is a non-opioid drug, which means that it cannot be administered with the help of a catheter. Intrathecal baclofen is not a controlled drug, which means that it cannot be administered by the administration of a catheter. Intrathecal baclofen is a relatively inexpensive drug, which means that it can be administered with the help of a catheter, which is a relatively slow catheter. Intrathecal baclofen is a drug that can be administered by the administration of a catheter. Intrathecal baclofen is an alternative to oral drugs in the treatment of spasticity. It can be administered orally, either directly by the administration of a catheter, or it can be administered in the form of a capsule or tablet [
,
Intrathecal baclofen can be administered by the administration of a catheter, and it can be administered via an intrathecal route in the form of a capsule. It is a non-opioid drug that can be administered with a catheter, which is a relatively slow catheter [
Intrathecal baclofen is a drug that can be administered in the form of oral capsules, or it can be injected directly into the spasticity of a patient [
Intrathecal baclofen is a non-opioid drug, which means that it cannot be administered with the help of a catheter. Intrathecal baclofen is a drug that can be administered by the administration of a catheter, and it can be administered via an intrathecal route in the form of a capsule or tablet [
Baclofen is used to treat muscle spasms caused by various conditions. It is used to treat muscle spasticity caused by multiple sclerosis, spinal cord injury, or other diseases affecting the brain.
It is also used to treat severe muscle spasms due to cerebral palsy or other spinal disorders. It belongs to a class of drugs called antispasmodics. It works by blocking the movement of natural substances within the body, thereby reducing muscle spasms.
Baclofen belongs to a class of drugs known as atropine antibiotics. It works by blocking the production of natural substances in the body, thereby reducing muscle spasms.
If you take baclofen too much or too little, your symptoms may get worse. This could lead to muscle spasms, loss of coordination, and paralysis. It can also cause dizziness, confusion, and difficulty speaking. If you experience any of these side effects, you should consult your doctor immediately.
It is important to follow the dosage instructions provided by your doctor. If you have any concerns about taking baclofen, you should consult your doctor.
Baclofen should not be used during pregnancy or while breastfeeding as it may harm the developing fetus. This medicine can harm the developing baby if taken during pregnancy.
Read More What Are BACLOFEN and How Do You Take It?If you are using baclofen, you must take it at the same time every day. Do not take this medicine more than once a day or you could cause stomach upset.
If you take baclofen, you must follow the dosage instructions provided by your doctor.
If you are pregnant or breastfeeding, you must consult your doctor immediately. It is important to note that baclofen passes into breast milk and may harm a nursing baby. This is only an advisory.
The most common side effects of baclofen are muscle pain, weakness, and coordination problems.
If you are taking baclofen, you must follow the dosage instructions provided by your doctor.
If you are taking baclofen, you must take it at the same time every day.
Read More What Are The Uses Of BACLOFEN? It works by blocking the production of natural substances within the body, thereby reducing muscle spasms. It can also treat severe muscle spasticity caused by cerebral palsy or other spinal disorders.
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